Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.

@article{Singh2011PrenatalSC,
  title={Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.},
  author={Shashi Prabha Singh and Sravanthi Gundavarapu and Juan Carlos Pe{\~n}a-Philippides and Jules Rir-sima-ah and Neerad C. Mishra and Julie A. Wilder and Raymond J Langley and Kevin R. Smith and Mohan L. Sopori},
  journal={Journal of immunology},
  year={2011},
  volume={187 9},
  pages={4542-52}
}
Parental, particularly maternal, smoking increases the risk for childhood allergic asthma and infection. Similarly, in a murine allergic asthma model, prenatal plus early postnatal exposure to secondhand cigarette smoke (SS) exacerbates airways hyperreactivity and Th2 responses in the lung. However, the mechanism and contribution of prenatal versus early postnatal SS exposure on allergic asthma remain unresolved. To identify the effects of prenatal and/or early postnatal SS on allergic asthma… CONTINUE READING

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