Prenatal programming of adult hypertension in the rat.

  title={Prenatal programming of adult hypertension in the rat.},
  author={V. Matti Vehaskari and Diego H. Aviles and Jennifer Manning},
  journal={Kidney international},
  volume={59 1},
BACKGROUND Epidemiological studies have suggested that low birthweight is a risk factor for the development of essential hypertension in adulthood, but the mechanism is unknown. METHODS A rat model of intrauterine growth retardation was employed. Pregnant Sprague-Dawley rats were kept on 6% protein or on control isocaloric 20% protein diet from gestational day 12 until term. Systolic blood pressures of the offspring were monitored by the tail cuff method. Apoptosis was determined by the TUNEL… CONTINUE READING
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