Prenatal prediction of risk of the fetal hydantoin syndrome.

  title={Prenatal prediction of risk of the fetal hydantoin syndrome.},
  author={Bruce A. Buehler and Duane C. Delimont and Michael van Waes and Richard H. Finnell},
  journal={The New England journal of medicine},
  volume={322 22},
The well-known teratogenicity of several anticonvulsant medications is associated with an elevated level of oxidative metabolites that are normally eliminated by the enzyme epoxide hydrolase. In this study, we attempted to determine whether infants who are at risk for congenital malformations could be identified prenatally by the measurement of epoxide hydrolase activity. Before fetuses at risk could be identified, it was necessary to measure epoxide hydrolase activity in a randomly selected… CONTINUE READING