Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.

@article{Auharek2010PrenatalPP,
  title={Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.},
  author={Sarah Alves Auharek and Luiz Renato de França and Chris McKinnell and Matthew S. Jobling and Hayley M. Scott and Richard M. Sharpe},
  journal={Endocrinology},
  year={2010},
  volume={151 6},
  pages={2868-75}
}
Androgens may be important regulators of Sertoli cell (SC) proliferation perinatally, with implications for the testicular dysgenesis syndrome (TDS) hypothesis. Fetal exposure of rats to 500 mg/kg . d di(n-butyl) phthalate (DBP) reduces fetal testosterone production and SC number at birth, but SC number recovers to normal by postnatal d (Pnd)25. It is unclear when and how SC proliferation is affected prenatally by DBP exposure or when and how postnatal compensation occurs. This study addressed… CONTINUE READING

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