Prenatal paracetamol exposure and child neurodevelopment: A review

@article{Bauer2018PrenatalPE,
  title={Prenatal paracetamol exposure and child neurodevelopment: A review},
  author={Ann Z Bauer and David W. Kriebel and Martha Herbert and Carl-Gustaf Bornehag and Shanna Helen Swan},
  journal={Hormones and Behavior},
  year={2018},
  volume={101},
  pages={125-147}
}
Background: The non‐prescription medication paracetamol (acetaminophen, APAP) is currently recommended as a safe pain and fever treatment during pregnancy. However, recent studies suggest a possible association between APAP use in pregnancy and offspring neurodevelopment. Objectives: To conduct a review of publications reporting associations between prenatal APAP use and offspring neurodevelopmental outcomes. Methods: Relevant sources were identified through a key word search of multiple… 
Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children
TLDR
Timing of exposure and short-term use of paracetamol during pregnancy do not seem to pose any substantial risk of the outcomes examined and unmeasured confounders play an important role and may potentially bias the effect estimates away from the null.
Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.
TLDR
Given the high prevalence of use, findings regarding intrauterine exposure to acetaminophen on multiple child health outcomes raise concerns and research on causal and non-causal mechanisms that might explain these associations should be a priority.
Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis
TLDR
The timing and duration of acetaminophen use during pregnancy may have a major effect on the risk of attention deficit/hyperactivity disorder in offspring.
Associations between paracetamol (acetaminophen) intake between 18 and 32 weeks gestation and neurocognitive outcomes in the child: A longitudinal cohort study
TLDR
If paracetamol use in mid‐to‐late pregnancy has an adverse effect on child neurocognitive outcome, it appears to mainly relate to the pre‐school period.
Acetaminophen is not Safe in Pregnancy
  • 2018
A narrative review of risks of acetaminophen to the fetus is conducted. Prenatal exposure to acetaminophen is associated with cerebral palsy, autism spectrum disorder, communication problems,
The association between analgesic drug use in pregnancy and neurodevelopmental disorders: protocol for an umbrella review
TLDR
An umbrella review of associations between maternal prenatal use of analgesic drugs and children’s neurodevelopmental disorders could allow for firmer conclusions to be drawn through the synthesis of all relevant published research.
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts
TLDR
Prenatal exposure to acetaminophen was associated with ASC or ADHD symptoms and boys and girls showed higher odds for ASC and ADHD symptoms after prenatal exposure, though these associations were slightly stronger among boys.
Gestational exposure to paracetamol in rats induces neurofunctional alterations in the progeny.
TLDR
Evaluated potential of PAR to induce developmental neurotoxicity in rats and observed alterations may be relevant for neurodevelopmental disorders suggest PAR as a developmental neurotoxicant.
Paracetamol (Acetaminophen) and the Developing Brain
TLDR
The data analyzed point to a dose–effect relationship but cannot fully account for unmeasured confounders, notably indication and genetic transmission, which deserves further investigation.
Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort
TLDR
Offspring of mothers who used acetaminophen before pregnancy had a higher risk of low birthweight and small for gestational age and Acetaminophen use during pregnancy was not associated with the examined outcomes.
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