Prenatal origin of acute lymphoblastic leukaemia in children

  title={Prenatal origin of acute lymphoblastic leukaemia in children},
  author={J Wiemels and Giovanni Cazzaniga and Maria Daniotti and O. B. Eden and M Greaves},
  journal={The Lancet},
BACKGROUND There is little current insight into the natural history of childhood leukaemia or the timing of relevant mutational events. TEL-AML1 gene fusion due to chromosomal translocation is frequently seen in the common form of childhood acute lymphoblastic leukaemia. We investigated whether this abnormality arises prenatally. METHODS We identified, by reverse-transcriptase PCR screening of blood or bone marrow, TEL-AML1 fusion in 12 children, plus a pair of identical twins, aged 2-5 years… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 237 extracted citations

Exposure to infections and risk of leukemia in young children.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2014
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…