Prenatal origin of acute lymphoblastic leukaemia in children

@article{Wiemels1999PrenatalOO,
  title={Prenatal origin of acute lymphoblastic leukaemia in children},
  author={J Wiemels and Giovanni Cazzaniga and Maria Daniotti and O. B. Eden and M Greaves},
  journal={The Lancet},
  year={1999},
  volume={354},
  pages={1499-1503}
}
BACKGROUND There is little current insight into the natural history of childhood leukaemia or the timing of relevant mutational events. TEL-AML1 gene fusion due to chromosomal translocation is frequently seen in the common form of childhood acute lymphoblastic leukaemia. We investigated whether this abnormality arises prenatally. METHODS We identified, by reverse-transcriptase PCR screening of blood or bone marrow, TEL-AML1 fusion in 12 children, plus a pair of identical twins, aged 2-5 years… CONTINUE READING

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