Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review
@article{Murk2011PrenatalOE, title={Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review}, author={William K Murk and Kari Ravndal Risnes and Michael B. Bracken}, journal={Pediatrics}, year={2011}, volume={127}, pages={1125 - 1138} }
CONTEXT: The increasing prevalence of childhood asthma has been associated with low microbial exposure as described by the hygiene hypothesis. OBJECTIVE: We sought to evaluate the evidence of association between antibiotic exposure during pregnancy or in the first year of life and risk of childhood asthma. METHODS: PubMed was systematically searched for studies published between 1950 and July 1, 2010. Those that assessed associations between antibiotic exposure during pregnancy or in the first…
257 Citations
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Although most studies showed significant findings between early antibiotic exposure and asthma, the actual effects are still unclear as intrapartum antibiotic administration, familial factors and confounding by maternal and child infections were often not addressed.
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It is indicated that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms.
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Previous positive associations between exposure to antibiotics in fetal and early life and subsequent childhood asthma could have been caused by confounding by shared familial factors, in addition to confounding by respiratory infections.
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