Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review

  title={Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review},
  author={William K Murk and Kari Ravndal Risnes and Michael B. Bracken},
  pages={1125 - 1138}
CONTEXT: The increasing prevalence of childhood asthma has been associated with low microbial exposure as described by the hygiene hypothesis. OBJECTIVE: We sought to evaluate the evidence of association between antibiotic exposure during pregnancy or in the first year of life and risk of childhood asthma. METHODS: PubMed was systematically searched for studies published between 1950 and July 1, 2010. Those that assessed associations between antibiotic exposure during pregnancy or in the first… 

Figures from this paper

The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review
Although most studies showed significant findings between early antibiotic exposure and asthma, the actual effects are still unclear as intrapartum antibiotic administration, familial factors and confounding by maternal and child infections were often not addressed.
Prenatal antibiotic exposure and childhood asthma: a population-based study
Prenatal antibiotic exposure was associated with a dose-dependent increase in asthma risk, but similar associations were observed for maternal antibiotic use before and after pregnancy, suggesting the association is either not directly causal, or not specific to pregnancy.
Antibiotic exposure during pregnancy and childhood asthma: a national birth cohort study investigating timing of exposure and mode of delivery
Antibiotic exposure in mid-to-late pregnancy is associated with higher odds of childhood asthma in vaginally born children, but not those born by caesarean section, and mode of delivery may modify the association.
Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis.
First-Year Antibiotics Exposure in Relation to Childhood Asthma, Allergies, and Airway Illnesses
It is indicated that first-year antibiotics exposure could be a strong risk factor for childhood pneumonia, asthma, allergies, and their related symptoms.
Relationship between prenatal antibiotic use and asthma in at-risk children.
  • B. Lapin, J. Piorkowski, V. Persky
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2015
Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis
Previous positive associations between exposure to antibiotics in fetal and early life and subsequent childhood asthma could have been caused by confounding by shared familial factors, in addition to confounding by respiratory infections.
Association Between Early-Childhood Antibiotic Exposure and Subsequent Asthma in the US Medicaid Population.
Association between early life (prenatal and postnatal) antibiotic administration and coeliac disease: a systematic review
A large, multicentre cohort study that evaluated the association between postnatal antibiotic exposure and CD autoimmunity in human leukocyte antigen (HLA)-positive subjects found no association.


Increased risk of childhood asthma from antibiotic use in early life.
Antibiotic use in early life was associated with the development of childhood asthma, a risk that may be reduced by avoiding the use of BS cephalosporins.
Antibiotic Use in Children Is Associated With Increased Risk of Asthma
Evidence is provided that the use of antibiotics in the first year of life is associated with a small risk of developing asthma, and this risk increases with the number of courses of antibiotics prescribed.
Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis.
Exposure to at least one course of antibiotics in the first year of life appears to be a risk factor for the development of childhood asthma.
Early life exposures and risk of atopy among Danish children.
Wheezy bronchitis before the age of 2 years seems to be independent of familial predisposition to atopic disease and significantly increases the likelihood for development of atopy in genetically susceptible individuals.
Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study
Repeated viral infections other than lower respiratory tract infections early in life may reduce the risk of developing asthma up to school age.
Determinants of the incidence of childhood asthma: a two-stage case-control study.
This study allowed the authors to identify the most influential determinants of childhood asthma among 47 predictors assessed for the prenatal, perinatal, and childhood periods within a single study setting.
Lack of association between antibiotic use in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years.
The hypothesis that antibiotic use in early life is associated with the subsequent development of asthma and atopy in childhood is not supported.
Maternal infections in pregnancy and the development of asthma among offspring.
The results suggest that further investigation of the relation of maternal infections during pregnancy to asthma among children seems warranted.
The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands General Practice Database.
Investigating a birth cohort of 24,690 children, derived from the West Midlands General Practice Research Database, suggests exposure to antibiotics and to infections in utero is a potentially important risk factor in the development of allergic disease.
Fever, Use of Antibiotics, and Acute Gastroenteritis During Infancy as Risk Factors for the Development of Asthma in Korean School-Age Children
  • K. Ahn, M. Lee, Kyu-Earn Kim
  • Medicine
    The Journal of asthma : official journal of the Association for the Care of Asthma
  • 2005
The data suggest that the development of childhood asthma is associated with episodes of fever, antibiotic use, and acute gastroenteritis during infancy, as well as immunization during infancy.