Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice

@article{Alkam2017PrenatalNE,
  title={Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice},
  author={Tursun Alkam and Takayoshi Mamiya and Nami Kimura and Aya Yoshida and Daisuke Kihara and Yuki Tsunoda and Yuki Aoyama and Masayuki Hiramatsu and Hyoung-Chun Kim and Toshitaka Nabeshima},
  journal={Psychopharmacology},
  year={2017},
  volume={234},
  pages={1853-1869}
}
Increased risk of attention-deficit/hyperactivity disorder (AD/HD) is partly associated with the early developmental exposure to nicotine in tobacco smoke. Emerging reports link tobacco smoke exposure or prenatal nicotine exposure (PNE) with AD/HD-like behaviors in rodent models. We have previously reported that PNE induces cognitive behavioral deficits in offspring and decreases the contents of dopamine (DA) and its turnover in the prefrontal cortex (PFC) of offspring It is well known that the… CONTINUE READING