Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations.

@article{Muneoka1997PrenatalNE,
  title={Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations.},
  author={Katsumasa T Muneoka and Toru Ogawa and Kenshi Kamei and Soichi Muraoka and R Tomiyoshi and Yasuhiro Mimura and Hideaki Kato and Melissa R Suzuki and Morikuni Takigawa},
  journal={Brain research. Developmental brain research},
  year={1997},
  volume={102 1},
  pages={117-26}
}
The present study was undertaken to examine the effects of prenatal nicotine exposure by two different routes of drug administration, injection and infusion, on the development of monoaminergic systems and open field behavior in the neonatal and juvenile rat. The nicotine administration to pregnant Sprague-Dawley rats was carried out by subcutaneous injection (3 mg/kg twice daily) or infusion via implanted osmotic minipumps (6 mg/kg/day) from gestational day 4 (GD4) until GD20. At postnatal day… CONTINUE READING