Prenatal lens development in connexin43 and connexin50 double knockout mice.

@article{White2001PrenatalLD,
  title={Prenatal lens development in connexin43 and connexin50 double knockout mice.},
  author={Thomas W. White and Caterina Sellitto and David L. Paul and Daniel A. Goodenough},
  journal={Investigative ophthalmology & visual science},
  year={2001},
  volume={42 12},
  pages={2916-23}
}
PURPOSE To determine the roles of intercellular communication in embryonic eye growth and development, mice with a targeted deletion of the Cx43 gene were examined, and mice without both Cx43 and Cx50 were generated and analyzed. METHODS Embryonic eyes and lenses from wild-type mice, or mice deficient in Cx43, Cx50, or both Cx43 and Cx50 were collected and analyzed structurally by light and electron microscopy, immunohistochemically using connexin-specific antibodies, biochemically by Western… CONTINUE READING