Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

  title={Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene},
  author={Qi Zhao and Richard R. Behringer and B. de Crombrugghe},
  journal={Nature Genetics},
The paired-class homeobox–containing gene, Cartl, is expressed in forebrain mesenchyme, branchial arches, limb buds and cartilages during embryogenesis. Here, we show that Cart1–homozygous mutant mice are born alive with acrania and meroanencephaly but die soon after birth — a phenotype that strikingly resembles a corresponding human syndrome caused by a neural tube closure defect. Developmental studies suggest that Cart1 is required for forebrain mesenchyme survival and that its absence… 

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