Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.

@article{Kirchner2010PrenatalET,
  title={Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.},
  author={S{\'e}verine Kirchner and Tiffany Kieu and Connie S Chow and Stephanie C. Casey and Bruce Blumberg},
  journal={Molecular endocrinology},
  year={2010},
  volume={24 3},
  pages={526-39}
}
The environmental obesogen hypothesis proposes that pre- and postnatal exposure to environmental chemicals contributes to adipogenesis and the development of obesity. Tributyltin (TBT) is an agonist of both retinoid X receptor (RXR) and peroxisome proliferator-activated receptor gamma (PPARgamma). Activation of these receptors can elevate adipose mass in adult mice exposed to the chemical in utero. Here we show that TBT sensitizes human and mouse multipotent stromal stem cells derived from… CONTINUE READING

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