Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice†

@article{Rattan2017PrenatalET,
  title={Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice†},
  author={Saniya Rattan and Emily Brehm and Liying Gao and S. Niermann and J. Flaws},
  journal={Biology of Reproduction},
  year={2017},
  volume={98},
  pages={130 - 145}
}
Abstract Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer found in polyvinyl chloride products such as vinyl flooring, plastic food containers, medical devices, and children's toys. DEHP is a ubiquitous environmental contaminant and is a known endocrine disrupting chemical. Little is known about the effects of prenatal DEHP exposure on the ovary and whether effects occur in subsequent generations. Thus, we tested the hypothesis that prenatal exposure to DEHP disrupts ovarian functions in the… Expand
Di(2-Ethylhexyl) Phthalate Exposure During Prenatal Development Causes Adverse Transgenerational Effects on Female Fertility in Mice
TLDR
Testing the hypothesis that prenatal exposure to DEHP accelerates the onset of puberty, disrupts estrous cyclicity, disrupteds birth outcomes, and reduces fertility in the F1, F2, and F3 generations of female mice indicates that prenatal DEHP exposure causes female reproductive problems in a multigenerational and transgenerational manner. Expand
Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice
TLDR
The hypothesis that transgenerational DEHP exposure alters anxiety-like behavior and neural gene expression in both male and female mice is tested and implicate dose-specific transgenerations effects on behavior and Neural gene expression on adult male andFemale mice. Expand
Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries.
TLDR
Overall, the data show that prenatal and ancestral DEHP greatly suppresses gene expression of pathways required for folliculogenesis and steroidogenesis in the ovary in a transgenerational manner and that gene expression may be in influenced by DNA methylation. Expand
Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse.
TLDR
The results indicate that 10 days of exposure to DEHP and DiNP changed the distribution of ovarian follicle populations and sex steroid hormones at multiple time points, including the last time point, 9 months post-dosing. Expand
Subchronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice
  • C. Chiang, J. Flaws
  • Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2019
TLDR
The data show that DEHP and DiNP exposure has long-term consequences for female reproduction, even long after cessation of exposure. Expand
Lactational Exposure to Di (2-ethylhexyl) Phthalate Impairs the Ovarian and Uterine Function of Adult Offspring Rat
TLDR
It is suggested that lactational exposure to DEHP has transgenerational effect on female reproductive system and this finding suggest that lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP from postnatal day 1 to 21, and the effects were evaluated in the ovary and uterus of F1 progeny rats. Expand
Prenatal exposure to di-(2-ethylhexyl) phthalate and high-fat diet synergistically disrupts mouse fetal oogenesis and affects folliculogenesis†
TLDR
It is found that treatment with an environmentally relevant dosage of DEHP and consumption of high-fat diet significantly increases synapsis defects in meiosis and affects folliculogenesis in the F1 generation. Expand
Prenatal Exposure to a Phthalate Mixture Leads to Multigenerational and Transgenerational Effects on Uterine Morphology and Function in Mice.
TLDR
It is demonstrated that prenatal exposure to an environmentally relevant phthalate mixture can have adverse effects on female reproductive functions. Expand
Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver.
TLDR
It is established that prenatal and ancestral DEHP exposure are critical for epigenetic regulation of DNA methylation in female mouse livers. Expand
Prenatal exposure to an environmentally relevant phthalate mixture disrupts testicular steroidogenesis in adult male mice.
TLDR
Pregnant CD-1 mice were orally dosed with a vehicle or the phthalate mixtures and those prenatally exposed mice had significantly lower serum testosterone concentrations accompanied by the decreased mRNA expression of testicular steroidogenic genes (StAR, Cyp11, and Cyp17) and impaired spermatogenesis. Expand
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TLDR
Prenatal DEHP exposure alters F1 sex ratio, increases preantral follicle numbers, and causes some breeding abnormalities, and the results indicate that prenatalDEHP exposure increased male-to-female ratio compared to controls. Expand
Lactational Exposure to Di (2-ethylhexyl) Phthalate Impairs the Ovarian and Uterine Function of Adult Offspring Rat
TLDR
It is suggested that lactational exposure to DEHP has transgenerational effect on female reproductive system and this finding suggest that lactating dams were exposed via oral gavage to corn oil (vehicle) and DEHP from postnatal day 1 to 21, and the effects were evaluated in the ovary and uterus of F1 progeny rats. Expand
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An increase in the number of ovarian atretic tertiary follicles was the only effect observed in adult female offspring exposed in utero and during lactation to DEHP, and Morphometric analysis indicated that uterus and vagina luminal epithelial cell height were unaffected by treatment. Expand
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TLDR
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TLDR
The hypothesis that acute DEHP exposure causes infertility, disrupts estrous cyclicity, alters hormone levels, and depletes follicle numbers by inducing atresia later in life, leading to accelerated reproductive aging is tested. Expand
Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse
TLDR
The results show that DEHP may have a number of adverse effects on oogenesis, especially when exposure occurs during early postnatal age, arising concerns about the exposure of human female infants and children to this compound. Expand
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