Prenatal exposure to cocaine decreases adenylyl cyclase activity in embryonic mouse striatum.

@article{Unterwald2003PrenatalET,
  title={Prenatal exposure to cocaine decreases adenylyl cyclase activity in embryonic mouse striatum.},
  author={Ellen M. Unterwald and Sanja Kutnjak Ivkovi{\'c} and Marie Cuntapay and Antonella Stroppolo and B{\'a}rbara Guinea and Michelle E Ehrlich},
  journal={Brain research. Developmental brain research},
  year={2003},
  volume={147 1-2},
  pages={67-75}
}
Adenylyl cyclase activity was measured in the striatum of naive mice as a function of age and in mice exposed in utero to cocaine. In naive Swiss-Webster mice, basal and forskolin-stimulated adenylyl cyclase activity increased gradually from embryonic day 13 (E13) until 2-3 weeks of age when activity peaked before decreasing slightly to adult levels. The ability of the dopamine D1 receptor agonist, SKF 82958, to stimulate adenylyl cyclase activity also increased in magnitude until P15. In a… CONTINUE READING