Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice.

@article{Niedzwiecki2012PrenatalET,
  title={Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice.},
  author={Megan M Niedzwiecki and Huaijie Zhu and Lin Corson and Gabriele Grunig and Phillip Factor and Shaomin Chu and H Jiang and Rachel L Miller},
  journal={Allergy},
  year={2012},
  volume={67 7},
  pages={904-10}
}
BACKGROUND Prenatal allergen exposure has been linked to both induction and protection of allergic sensitization in offspring. We hypothesized that prenatal exposure of mice (F0) to Aspergillus fumigatus (A. fumigatus) would be associated with decreased immunoglobulin (Ig) E and airway eosinophilia and alterations in CpG methylation of T-helper genes in third-generation mice (F2). METHODS Female BALB/c mice were sensitized to A. fumigatus (62.5, 125, 1250 μg, or saline) and re-exposed to the… CONTINUE READING
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