Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.

@article{Chawanthayatham2015PrenatalEO,
  title={Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.},
  author={Supawadee Chawanthayatham and Apinya Thiantanawat and Patricia A. Egner and John D. Groopman and Gerald N. Wogan and Robert G. Croy and John M Essigmann},
  journal={International journal of cancer},
  year={2015},
  volume={136 6},
  pages={1254-62}
}
It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxin B1 (AFB1 ) during prenatal development and the risk of later life genetic disease. AFB1 was given to pregnant C57BL/6J mice, carrying F1 gestation day 14 (GD14) embryos of the… CONTINUE READING