Prenatal experience and postnatal stress modulate the adult neurosteroid and catecholaminergic stress responses.

@article{Zimmerberg1998PrenatalEA,
  title={Prenatal experience and postnatal stress modulate the adult neurosteroid and catecholaminergic stress responses.},
  author={Betty Zimmerberg and Rachel C. Brown},
  journal={International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience},
  year={1998},
  volume={16 3-4},
  pages={217-28}
}
Allopregnanolone (3 alpha-hydroxy-5 alpha-regnan-20-one) is a neuroactive steroid recently shown to be involved in the neurochemical stress response via its positive modulation of the GABAA receptor complex. This experiment investigated the effects of postnatal stress (daily maternal separation during the first week of life) on the subsequent adult response to a stressor (10 min forced swim) in Long-Evans rats from one of three prenatal treatment groups (alcohol, pair-fed and control). Indices… CONTINUE READING