Prenatal diagnosis of partial trisomy 3p (3p21-->pter) and partial monosomy 11q (11q23-->qter) associated with abnormal sonographic findings of holoprosencephaly, orofacial clefts, pyelectasis and a unilateral duplex renal system.

@article{Chen2008PrenatalDO,
  title={Prenatal diagnosis of partial trisomy 3p (3p21-->pter) and partial monosomy 11q (11q23-->qter) associated with abnormal sonographic findings of holoprosencephaly, orofacial clefts, pyelectasis and a unilateral duplex renal system.},
  author={Chih-Ping Chen and Tzu-Hao Wang and Chyi-chyang Lin and Fuu-Jen Tsai and L Hsieh and Wayseen Wang},
  journal={Journal of the Formosan Medical Association = Taiwan yi zhi},
  year={2008},
  volume={107 10},
  pages={822-6}
}
Patients with partial trisomy 3p seldom present major dysmorphic features, and holoprosencephaly occurs in only 10% of the cases with partial trisomy 3p. It has been suggested that multiple genetic hits or environmental exposures are required for the clinical expression of holoprosencephaly. At 16 weeks of gestation, prenatal sonography identified a fetus… CONTINUE READING