Prenatal diagnosis of cystic fibrosis: microvillar enzymes and DNA analysis compared.

@article{Buffone1988PrenatalDO,
  title={Prenatal diagnosis of cystic fibrosis: microvillar enzymes and DNA analysis compared.},
  author={Gregory J. Buffone and Jennifer E Spence and Susan D. Fernbach and Martha R. Curry and William E O'brien and Arthur L Beaudet},
  journal={Clinical chemistry},
  year={1988},
  volume={34 5},
  pages={933-7}
}
We have established reference ranges for three microvillar intestinal enzymes--alkaline phosphatase (EC 3.1.3.1), gamma-glutamyltransferase (EC 2.3.2.1), and leucine aminopeptidase (EC 3.4.1.1)--measured in amniotic fluid in a reference population of 1875 women presenting for routine amniocentesis. These data were derived for use in prenatal diagnostic studies in a population at risk (1:4) for cystic fibrosis. False-positive or indeterminate results were noted for fewer than 3.5% of all low… CONTINUE READING