Prenatal diagnosis of congenital heart defect by genome-wide high-resolution SNP array.

@article{Liao2014PrenatalDO,
  title={Prenatal diagnosis of congenital heart defect by genome-wide high-resolution SNP array.},
  author={Can Liao and Ru Li and Fang Fang Fu and Guie Xie and Yongling Zhang and Min Pan and Jian Li and Dongzhi Li},
  journal={Prenatal diagnosis},
  year={2014},
  volume={34 9},
  pages={858-63}
}
OBJECTIVE This study aimed to detect genomic imbalances in fetuses with congenital heart defect (CHD) by high-resolution single-nucleotide polymorphism (SNP) array. METHODS A total of 99 fetuses with CHDs with or without other ultrasound anomalies (including structural anomalies and soft markers) but normal karyotypes were investigated using Affymetrix CytoScan HD array. RESULTS Clinical significant copy number variations (CNVs) were detected in 19 fetuses (19.2%). The proportion for… CONTINUE READING
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