Prenatal dexamethasone use for the prevention of virilization in pregnancies at risk for classical congenital adrenal hyperplasia because of 21‐hydroxylase (CYP21A2) deficiency: a systematic review and meta‐analyses

@article{MercFernndezBalsells2010PrenatalDU,
  title={Prenatal dexamethasone use for the prevention of virilization in pregnancies at risk for classical congenital adrenal hyperplasia because of 21‐hydroxylase (CYP21A2) deficiency: a systematic review and meta‐analyses},
  author={M Merc{\`e} Fern{\'a}ndez-Balsells and Kalpana Muthusamy and Galina Smushkin and Julianna F. Lampropulos and Mohamed B. Elamin and Nisrin O. Abu Elnour and Khalid B. Elamin and Neera Agrwal and Juan Fernando Gallegos-Orozco and Melanie A. Lane and Patricia J. Erwin and Victor M. Montori and M. Hassan Murad},
  journal={Clinical Endocrinology},
  year={2010},
  volume={73}
}
Context  Prenatal treatment with dexamethasone to prevent virilization in pregnancies at risk for classical congenital adrenal hyperplasia (CAH) remains controversial. 
Efficacy and safety of prenatal dexamethasone treatment in offspring at risk for congenital adrenal hyperplasia due to 21‐hydroxylase deficiency: A systematic review and meta‐analysis
TLDR
To assess the efficacy and safety of prenatal dexamethasone treatment in offspring at risk for congenital adrenal hyperplasia, a large number of cases have been reported to have benefited from treatment with this drug.
Challenges in Prenatal Treatment with Dexamethasone.
TLDR
The short- and long-term outcomes for fetuses and pregnant women exposed to dexamethasone treatment, the ethical considerations that must be taken into account, and current practice recommendations are reviewed.
Preventing female virilisation in congenital adrenal hyperplasia: The controversial role of antenatal dexamethasone
TLDR
Current controversies, potential improvements and future directions in the management of pregnancies at risk of CAH are summarized, including early prenatal diagnosis utilising noninvasive genetic techniques to minimise unnecessary dexamethasone exposure to unaffected fetuses.
Pregnancy in women with nonclassic congenital adrenal hyperplasia: Time to conceive and outcome
TLDR
The objective of this study was to evaluate the effect of glucocorticoid treatment on fertility and on pregnancy outcome in women with NCAH.
The importance and implications of preconception genetic testing for accurate fetal risk estimation in 21-hydroxylase congenital adrenal hyperplasia (CAH)
  • Suresh Rama ChandranL. Loh
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2019
TLDR
How the preconception genetic testing of a lady and her partner dramatically changed the estimated risk to their offspring and the major implications the results had on pregnancy planning are reported.
Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline.
Objective To update the congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency clinical practice guideline published by the Endocrine Society in 2010. Conclusions The writing
Congenital adrenal hyperplasia in pregnancy: approach depends on who is the ‘patient’
TLDR
Prenatal treatment for CAH and prenatal therapy for prevention of virilization of possibly affected female children, dexamethasone is used, however, questions remain about the efficacy and safety of exposing 7/8 unaffected children in the first trimester.
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