• Psychology, Medicine
• Published in
  Neurotoxicology and…
  1995
• DOI:10.1016/0892-0362(94)00074-n

Prenatal dexamethasone or stress but not ACTH or corticosterone alter sexual behavior in male rats.

@article{Holson1995PrenatalDO,
  title={Prenatal dexamethasone or stress but not ACTH or corticosterone alter sexual behavior in male rats.},
  author={R. Robert Holson and Bobby Gough and Patricia Sullivan and Troy J. Badger and Daniel M. Sheehan},
  journal={Neurotoxicology and teratology},
  year={1995},
  volume={17 4},
  pages={
          393-401
        }
}

• R. Robert Holson, Bobby Gough, +2 authors Daniel M. Sheehan

Prenatal maternal stress in rats and mice can demasculinize and feminize the sexual behavior of adult male offspring. Causal mechanisms are unknown, but one attractive hypothesis is that stress activation of maternal adrenal glucocorticoid secretion is the responsible agent. To test this hypothesis, pregnant rats were exposed to a variety of substances which enhance glucocorticoid actions. These included ACTH (20 IU of a gel preparation, SC once daily), corticosterone (CORT; 7 mg/kg SC in oil… CONTINUE READING

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