Prenatal dexamethasone exposure in rats: effects of dose, age at exposure, and drug-induced hypophagia on malformations and fetal organ weights.

@article{Lborde1992PrenatalDE,
  title={Prenatal dexamethasone exposure in rats: effects of dose, age at exposure, and drug-induced hypophagia on malformations and fetal organ weights.},
  author={J B L{\'a}borde and Deborah K. Hansen and John Fariselli Young and Daniel M. Sheehan and R. Robert Holson},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1992},
  volume={19 4},
  pages={545-54}
}
Glucocorticoids cause stunting and cleft palate in rodents. The aim of this study is to identify fetal organs and developmental periods sensitive to stunting induced by maternal exposure to dexamethasone (DEX). DEX (0.2 or 0.4 mg/kg) or saline was given sc to pregnant CD albino rats on Gestation Days (GD) 9-14 or 14-19. On GD 20 dams were euthanized. Fetuses were weighed and examined for cleft palate. Eight fetuses/litter were randomly selected, and weights were obtained. Fetal skeletons were… CONTINUE READING