Prenatal detection of fetal Down's syndrome from maternal plasma.

@article{Poon2000PrenatalDO,
  title={Prenatal detection of fetal Down's syndrome from maternal plasma.},
  author={Leo L M Poon and Tse Ngong Leung and Tze Kin Lau and Y. M. Lo},
  journal={Lancet},
  year={2000},
  volume={356 9244},
  pages={1819-20}
}
Fetal DNA is present in maternal plasma, and a proportion of such DNA is seen in intact fetal cells. We investigated the use of fluorescence in-situ hybridisation (FISH) techniques on maternal plasma samples. In plasma samples obtained from three women carrying fetuses affected by trisomy 21 (Down's syndrome), we identified fetal cells with three chromosome… CONTINUE READING