Prenatal detection and early diagnosis of hereditary retinoblastoma in a family.

@article{Pierro1993PrenatalDA,
  title={Prenatal detection and early diagnosis of hereditary retinoblastoma in a family.},
  author={Luisa Pierro and Rosario Brancato and Carlo Capoferri},
  journal={Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde},
  year={1993},
  volume={207 2},
  pages={106-11}
}
A couple asked for prenatal testing, the husband being a retinoblastoma survivor. Family history suggested that the tumor predisposing mutation came from his paternal side. DNA analysis indicated that the foetus had not inherited that mutation. Detection of a regressed retinoblastoma in the husband's mother changed the interpretation of the haplotypes… CONTINUE READING