Prenatal cocaine and cell development in rat brain regions: Effects on ornithine decarboxylase and macromolecules

@article{Seidler1993PrenatalCA,
  title={Prenatal cocaine and cell development in rat brain regions: Effects on ornithine decarboxylase and macromolecules},
  author={Frederic J. Seidler and Theodore A. Slotkin},
  journal={Brain Research Bulletin},
  year={1993},
  volume={30},
  pages={91-99}
}
Prenatal cocaine exposure has been shown to cause neurobehavioral abnormalities. To determine whether effects on basic patterns of cell development underlie these functional deficits, we examined the aftermath of acute and chronic cocaine exposure on ontogenetic patterns of ornithine decarboxylase (ODC), a key regulator of cell replication/differentiation, DNA synthesis as monitored by [3H]thymidine incorporation, and markers of cell number (DNA content) and cell size (protein/DNA ratio… CONTINUE READING
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