Prenatal cocaine administration stimulates fetal brain tyrosine hydroxylase activity.

@article{Meyer1993PrenatalCA,
  title={Prenatal cocaine administration stimulates fetal brain tyrosine hydroxylase activity.},
  author={Jerrold S. Meyer and Stefan A Dupont},
  journal={Brain research},
  year={1993},
  volume={608 1},
  pages={129-37}
}
Functional effects of prenatal cocaine exposure may be mediated in part by changes in catecholaminergic development. The present study examined whether cocaine administration influenced fetal brain activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Subcutaneous (s.c.) injection of pregnant rats with 40 mg/kg of cocaine HCl daily from gestational day (GD) 8 to GD20 resulted in an 8.7% stimulation of fetal whole-brain TH activity compared to controls… CONTINUE READING
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