Prenatal choline and the development of schizophrenia

  title={Prenatal choline and the development of schizophrenia},
  author={Robert Freedman and Randal G. Ross},
  journal={Shanghai Archives of Psychiatry},
  pages={90 - 102}
  • R. Freedman, R. Ross
  • Published 25 April 2015
  • Medicine, Psychology
  • Shanghai Archives of Psychiatry
Background The primary prevention of illness at the population level, the ultimate aim of medicine, seems out of reach for schizophrenia. Schizophrenia has a strong genetic component, and its pathogenesis begins long before the emergence of psychosis, as early as fetal brain development. Cholinergic neurotransmission at nicotinic receptors is a pathophysiological mechanism related to one aspect of this genetic risk. Choline activates these nicotinic receptors during fetal brain development… 

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