Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood.

@article{Spano2007PrenatalCE,
  title={Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood.},
  author={M Sabrina Spano and Maria Ellgren and Xiusong Wang and Yasmin L Hurd},
  journal={Biological psychiatry},
  year={2007},
  volume={61 4},
  pages={554-63}
}
BACKGROUND Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing. METHODS We used an animal model to study the effects of prenatal exposure to Delta(9)-tetrahydrocannabinol (THC) on heroin self-administration behavior and opioid neural systems in adult males (postnatal day 62). Rats were exposed to THC (.15 mg/kg) or vehicle from gestational day 5 to postnatal day 2… CONTINUE READING

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