Prenatal cadmium and ethanol increase amphetamine-evoked dopamine release in rat striatum.

@article{Nowak2006PrenatalCA,
  title={Prenatal cadmium and ethanol increase amphetamine-evoked dopamine release in rat striatum.},
  author={Przemysław Nowak and Joanna Dabrowska and Aleksandra Bortel and Biedka Izabela and Richard M. Kostrzewa and Ryszard Brus},
  journal={Neurotoxicology and teratology},
  year={2006},
  volume={28 5},
  pages={563-72}
}
To explore interactive deleterious effects of the teratogens ethanol and cadmium, pregnant rats were given cadmium (CdCl(2), 50 ppm) and/or ethanol (10%), or tap water (controls) in the drinking water for the entire 21 days of pregnancy. At 3 months after birth, in vivo microdialysis was used to determine that there was a 4000% evoked release of DA by AMPH (AMPH, 4.0 mg/kg i.p.) in the striatum of rats exposed prenatally to both ethanol and cadmium, vs. a 2000% evoked release by AMPH in rats… CONTINUE READING