Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder.

@article{Sullivan2004PrenatalAA,
  title={Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder.},
  author={Shannon D. Sullivan and Suzanne M. Moenter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 18},
  pages={
          7129-34
        }
}
Polycystic ovary syndrome, a fertility disorder affecting approximately 7% of women, is characterized by elevated androgens, disrupted reproductive cycles, and high luteinizing hormone, the latter reflecting increased gonadotropin-releasing hormone (GnRH) release. In animal models, a similar reproductive endocrine phenotype occurs after prenatal androgen exposure. To study the effects of in utero androgen exposure directly on GnRH neurons, the central regulators of fertility, we prenatally… CONTINUE READING

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