Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome

@article{Bruns2007PrenatalAE,
  title={Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome},
  author={C. M. Bruns and S. Baum and R. Colman and D. Dumesic and J. Eisner and M. Jensen and L. Whigham and D. Abbott},
  journal={International Journal of Obesity},
  year={2007},
  volume={31},
  pages={1579-1585}
}
Introduction:Prenatally androgenized (PA) female rhesus monkeys share metabolic abnormalities in common with polycystic ovary syndrome (PCOS) women. Early gestation exposure (E) results in insulin resistance, impaired pancreatic β-cell function and type 2 diabetes, while late gestation exposure (L) results in supranormal insulin sensitivity that declines with increasing body mass index (BMI).Objective:To determine whether PA females have altered body fat distribution.Design:Five early-treated… Expand
Polycystic ovary syndrome and its developmental origins
Early origins of polycystic ovary syndrome.
Perinatal androgen exposure and adipose tissue programming: is there an impact on body weight fate?
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