Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats.

@article{Yan2014PrenatalAE,
  title={Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats.},
  author={Xiaonan Yan and Chun Yuan and Nan-nan Zhao and Yugui Cui and Jia-yin Liu},
  journal={The Journal of endocrinology},
  year={2014},
  volume={222 1},
  pages={
          73-85
        }
}
In adolescent girls with polycystic ovary syndrome (PCOS), neuroendocrine derangements manifest after the onset of puberty, characterized by rapid LH pulse frequency. The early mechanism underlying the pubertal regulation of the GNRH/LH pulsatile release in adolescents with PCOS remains uncertain. To determine the effects of prenatal androgen exposure on the activation of GNRH neurons and generation of LH pulse at puberty, we administrated 5α-dihydrotestosterone to pregnant rats and observed… Expand
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