Prenatal and perinatal zinc restriction: effects on body composition, glucose tolerance and insulin response in rat offspring

@article{Padmavathi2009PrenatalAP,
  title={Prenatal and perinatal zinc restriction: effects on body composition, glucose tolerance and insulin response in rat offspring},
  author={Inagadapa J.N. Padmavathi and Yedla Durga Kishore and Lagishetty Venu and Manisha Ganeshan and Nemani Harishankar and Nappan Veettil Giridharan and Manchala Raghunath},
  journal={Experimental Physiology},
  year={2009},
  volume={94}
}
Maternal undernutrition increases the risk of adult chronic diseases, such as obesity and type 2 diabetes. This study evaluated the effect of maternal zinc restriction in predisposing the offspring to adiposity and altered insulin response in later life. Seventy‐day‐old female Wistar/NIN rats received a control (ZnC) or zinc‐restricted (ZnR) diet for 2 weeks. Following mating with control males, a subgroup of the ZnR dams were rehabilitated with ZnC diet from parturition. Half the offspring… 
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TLDR
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1Effects of zinc deficiency in male mice on glucose metabolism of male offspring
TLDR
Zinc deficiency in male mice can cause abnormal glucose homeostasis in male offspring, but not in female offspring, and F1 female mice in the low zinc group did not show abnormal glucose metabolism.
Maternal micronutrient restriction programs the body adiposity, adipocyte function and lipid metabolism in offspring: A review
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The role of maternal micronutrients in the foetal origins of adiposity is focused mainly on, with a view to insights into the probable underlying / associated mechanisms in the metabolic pathways of endocrine related complications.
Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: results from a randomized clinical trial
TLDR
The hypothesis that maternal zinc supplementation during pregnancy reduces the risk of offspring cardiometabolic disease is not supported.
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