Prenatal and early postnatal ontogenesis of the human motor cortex: a golgi study. I. The sequential development of the cortical layers.

Abstract

PoliakovT, s has pointed out that a definite sequence occurs in the development of the human cerebral cortex and that a distinct relationship appears to exist among the arrival of afferent inputs, the organization of the various cortical layers and the maturation of the cortical neurons. Except for the systematic studies of Poliakov and other Russian investigators TM little is known concerning the prenatal ontogenesis of the human cerebral cortex. The remaining available information on this subject is restricted to isolated reports1-5, 9 of some of the stages of cortical development, which fail to demonstrate the concatenation and the sequential nature of the entire process. Although information is more readily available concerning the postnatal development of the human cerebral cortex1,2, 5 this pertains mostly to the increasing complexity of cortical structures already present at the time of birth and it fails to demonstrate the sequential development of the different cortical structures during the course of cortical ontogenesis. Appreciation of the development of the cortical structures (the different neuronal types and systems of fibers and the cortical laminations) during the course of prenatal and early postnatal ontogenesis is a s ine qua non for the understanding of the structural-functional relationship of the cortex. Furthermore, this knowledge is of fundamental importance for interpretation of the unique morphological peculiarities of the structural organization of the cerebral cortex. This communication reports a series of observations made in a systematic investigation of the prenatal and early postnatal ontogenesis of the human motor cortex. Although this study was confined to the motor cortex and the cases investigated do not represent a complete developmental series, the findings are considered to be representative of the general sequential development of the human cerebral cortex. Many of the observations made in this investigation confirm those reported by Poliakov7, 8. To these some additional findings are now added. To facilitate their description and analysis, the findings of this investigation are

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@article{MarnPadilla1970PrenatalAE, title={Prenatal and early postnatal ontogenesis of the human motor cortex: a golgi study. I. The sequential development of the cortical layers.}, author={Miguel Mar{\'i}n-Padilla}, journal={Brain research}, year={1970}, volume={23 2}, pages={167-83} }