Corpus ID: 9161099

Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.

  title={Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.},
  author={Miryala Sandeep and Jose M Alvin},
  journal={Indian journal of experimental biology},
  volume={52 12},
Meclizine and caffeine combination is used for the treatment of morning sickness. Both compounds are teratogenic and caffeine is known to possess anti-fertility activity also. The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine combination. Three doses were taken for the study; low dose (LD; meclizine 3.7 mg/kg and caffeine 3 mg/kg) was selected from commercially available formulation, middle dose (MD; meclizine 37 mg/kg and caffeine 30 mg/kg… Expand
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  • S. S. Agrawal, M. Alvin Jose
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2009
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