Corpus ID: 9161099

Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.

@article{Sandeep2014PrenatalAD,
  title={Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats.},
  author={M. Sandeep and J. M. Alvin},
  journal={Indian journal of experimental biology},
  year={2014},
  volume={52 12},
  pages={
          1165-72
        }
}
Meclizine and caffeine combination is used for the treatment of morning sickness. Both compounds are teratogenic and caffeine is known to possess anti-fertility activity also. The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine combination. Three doses were taken for the study; low dose (LD; meclizine 3.7 mg/kg and caffeine 3 mg/kg) was selected from commercially available formulation, middle dose (MD; meclizine 37 mg/kg and caffeine 30 mg/kg… Expand
1 Citations
Mast cells as protectors of health.
TLDR
Proteases released by FcεRI-activated MCs detoxify an increasing number of venoms and endogenous toxins, which will help improve these advantageous effects and hint at ways to cut down detrimental MC actions. Expand

References

SHOWING 1-10 OF 63 REFERENCES
Intrauterine growth retardation and lack of teratogenic effects of prenatal exposure to the combination of paracetamol and caffeine in Wistar rats.
TLDR
Dose-dependent effects in the middle and high dose groups on fetal body weight/growth and placental weight were found and in none of the three dose groups was there an increase in external or internal congenital malformations. Expand
Studies on the teratogenic effects of different oral preparations of caffeine in mice.
TLDR
It would appear that the effect on the supraoccipital bones is an indirect one mediated through reduced food and water intake of the dams when caffeine is administered in drinking water. Expand
Acetazolamide with caffeine causes exencephaly in "resistant" SWV mice.
TLDR
Evidence is provided that ACZM, coupled with a subteratogenic dose of caffeine can produce abnormalities in the "resistant" SWV mice, using the endpoint of exencephaly on day 8 of gestation. Expand
Potentiating effect of caffeine on embryotoxicity of cyclophosphamide treatment in vivo during the preimplantation period.
TLDR
The data are providing evidence that CF at subthreshold doses can potentiate the embryotoxicity of an alkylating agent in vivo even before implantation, and suggest that CF can inhibit the repair of CPA-induced DNA damage in preimplantation embryos. Expand
Blood levels of caffeine and results of fetal examination after oral administration of caffeine to pregnant rats
TLDR
A comparison of autopsy results from both groups indicated that resorptions were increased when compared with rats that did not receive caffeine; this effect was more marked in the gavage group than in the ad libitum sipping group. Expand
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
TLDR
The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg, but similar potentiation was not observed for x-ray, MNNG, thio-TEPA, and cyclophosphamide. Expand
Blood flow changes and conceptal development in pregnant rats in response to caffeine.
TLDR
Blood flow to several maternal organs, including ovary, uterus, decidua, and chorioallantoic placenta (CAP), was measured following a single dose of 0 or 120 mg/kg caffeine to pregnant CD rats, indicating free transfer of caffeine to the embryos. Expand
Teratogen update: evaluation of the reproductive and developmental risks of caffeine.
TLDR
The objectives of the present review are to summarize the findings from the various clinical and animals studies, objectively discuss the merits and/or faults inherent in the studies and establish a global reproductive risk assessment for caffeine consumption in humans during pregnancy. Expand
Anti-implantation activity of H2 receptor blockers and meloxicam, a COX-inhibitor, in albino Wistar rats
  • S. S. Agrawal, M. Alvin Jose
  • Medicine
  • The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 2009
TLDR
The results indirectly confirm the combined involvement of histamine and prostaglandins in the implantation process, and the mast cell stabilising property of H2 blockers appears to be a possible mechanism for their anti-implantation activity. Expand
Effects of preconceptual caffeine exposure on pregnancy and progeny viability.
TLDR
It was concluded that the reduced fertility rate in preconceptually caffeine-exposed rats was due to the failure of litters to implant rather than to a reduced fertilization rate, which was normal. Expand
...
1
2
3
4
5
...