Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism

@inproceedings{Waly2012PrenatalAP,
  title={Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism},
  author={Mostafa Waly and Mady Hornig and Malav S Trivedi and Nathaniel Hodgson and Radhika Gopalkrishna Kini and Akio Ohta and Richard C. Deth},
  booktitle={Autism research and treatment},
  year={2012}
}
Although autism is first and foremost a disorder of the central nervous system, comorbid dysfunction of the gastrointestinal (GI) and immune systems is common, suggesting that all three systems may be affected by common molecular mechanisms. Substantial systemic deficits in the antioxidant glutathione and its precursor, cysteine, have been documented in autism in association with oxidative stress and impaired methylation. DNA and histone methylation provide epigenetic regulation of gene… CONTINUE READING
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