Prenatal administration of para-chlorophenylalanine results in suppression of serotonergic system and disturbance of swimming movements in newborn rats.


Postnatal development of the spinal cord serotonergic (5-HT) system and of swimming movements were studied in newborn Sprague-Dawley rats, in which the serotonin level in the central nervous system was lowered in the prenatal period. For this purpose, para-chlorophenylalanine (PCPA) (300 mg/kg) was administered intraperitoneally to pregnant mother rats on… (More)