Prenatal Therapy in Congenital Adrenal Hyperplasia Attempted Prevention of Abnormal External Genital Masculinization by Pharmacologic Suppression of the Fetal Adrenal Gland in Utero

@article{Chrousos1985PrenatalTI,
  title={Prenatal Therapy in Congenital Adrenal Hyperplasia Attempted Prevention of Abnormal External Genital Masculinization by Pharmacologic Suppression of the Fetal Adrenal Gland in Utero},
  author={George P. Chrousos and Mark I. Evans and D. Lynn Loriaux and James McCluskey and John C. Fletcher and Joseph D. Schulman},
  journal={Annals of the New York Academy of Sciences},
  year={1985},
  volume={458}
}
In severe congenital adrenal hyperplasia (CAH), the adrenal androgens secreted by the fetal adrenal gland are thought to masculinize the external genitalia of female fetuses between 10 and 16 weeks gestation.’-’ This is the period when the testes normally masculinize the bipotential genital tubercle and adjacent regions in male f e t ~ s e s . ~ ” Thus, suppression of the fetal pituitary-adrenal axis with a glucocorticoid compound during gestational weeks 10-16 should lead to prevention of… 
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Acute Encephalopathy with Unilateral Cortical-Subcortical Lesions in Two Unrelated Kindreds Treated with Glucocorticoids Prenatally for Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: Established Facts and Novel Insight
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2 children with CAH, both treated prenatally with high doses of dexamethasone to prevent virilization are reported, posing a risk factor for brain lesions in later life.
A contribution to the classification of cases of non-classic 21-hydroxylase-deficient congenital adrenal hyperplasia.
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It seems that Groups I, II and III include, respectively, patients with severe, mild and minimal forms of non-classic 21-hydroxylase-deficient CAH, while in patients of Group IV the hyperandrogenemic symptoms are of different etiology.
Effects of Maternal Dexamethasone Treatment Early in Pregnancy on Glucocorticoid Receptors in the Ovine Placenta
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It is speculated that 3 maturational stages of BNCs exist and that the overall activity of B NCs is determined by the distribution of these 3 cell types, which may become altered through early pregnancy exposure to elevated glucocorticoids.
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TLDR
This study demonstrates prolonged suppression of the fetal adrenal gland with dexamethasone and suggests it might prevent abnormal masculinization in fetuses with severe congenital adrenal hyperplasia.
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