Prenatal T cell immunity to Wuchereria bancrofti and its effect on filarial immunity and infection susceptibility during childhood.

@article{Malhotra2006PrenatalTC,
  title={Prenatal T cell immunity to Wuchereria bancrofti and its effect on filarial immunity and infection susceptibility during childhood.},
  author={Indu J Malhotra and Peter L. Mungai and Alex N. Wamachi and Daniel J. Tisch and John Masila Kioko and John Henry Ouma and Eric M. Muchiri and James W. Kazura and Christopher L King},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={193 7},
  pages={1005-13}
}
BACKGROUND Antenatal immune experience with Wuchereria bancrofti due to maternal filariasis may influence susceptibility to infection. We tested the hypothesis that filarial-specific T cell responses at birth that are indicative of in utero tolerance or sensitization affect the evolution of filarial-specific immunity and susceptibility to W. bancrofti infection during childhood. METHODS A birth-cohort study of 159 Kenyan newborns was performed. Cord blood and peripheral blood were obtained… CONTINUE READING
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