Prenatal Stress Depresses Immune Function in Rats

  title={Prenatal Stress Depresses Immune Function in Rats},
  author={Gillian Kay and Nora Tarcic and Tatyana Poltyrev and M Weinstock},
  journal={Physiology & Behavior},
The aim of the present study was to determine the effect of prenatal stress on immune function in rats. Pregnant rats were stressed by noise and light, three times weekly throughout pregnancy. Experiments were performed on male and female offspring aged 2 months. Cellular immune responses of splenic lymphocytes to B-cell (pokeweed mitogen (PWM) and T-cell (phytohemagglutinin (PHA)) mitogens were measured by [3H]thymidine uptake, and natural killer (NK) cell cytotoxicity in blood and splenic… CONTINUE READING


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