Prenatal Polycyclic Aromatic Hydrocarbon, Adiposity, Peroxisome Proliferator-Activated Receptor (PPAR) γ Methylation in Offspring, Grand-Offspring Mice

@inproceedings{Yan2014PrenatalPA,
  title={Prenatal Polycyclic Aromatic Hydrocarbon, Adiposity, Peroxisome Proliferator-Activated Receptor (PPAR) γ Methylation in Offspring, Grand-Offspring Mice},
  author={Zhonghai Yan and Hanjie Zhang and Christina Maher and Emilio Arteaga-Solis and F. Champagne and Licheng Wu and Jacob D Mcdonald and Beizhan Yan and Gary J Schwartz and Rachel L Miller},
  booktitle={PloS one},
  year={2014}
}
RATIONALE Greater levels of prenatal exposure to polycyclic aromatic hydrocarbon (PAH) have been associated with childhood obesity in epidemiological studies. However, the underlying mechanisms are unclear. OBJECTIVES We hypothesized that prenatal PAH over-exposure during gestation would lead to weight gain and increased fat mass in offspring and grand-offspring mice. Further, we hypothesized that altered adipose gene expression and DNA methylation in genes important to adipocyte… CONTINUE READING
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