Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring.

@article{Chen2012PrenatalPE,
  title={Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring.},
  author={Tian Chen and Ling Zhang and J. Yue and Zi-quan Lv and Wei Xia and Yan-jian Wan and Yuan-yuan Li and Shun-qing Xu},
  journal={Reproductive toxicology},
  year={2012},
  volume={33 4},
  pages={
          538-545
        }
}
Perfluorooctane sulfonate (PFOS) could induce neonatal pulmonary injuries in rodents. The aim of this study was to investigate the underlying mode of action. Pregnant rats were dosed orally with PFOS (0, 0.1 and 2.0mg/kgd) from gestation days (GD) 1 to 21. Lung samples from postnatal day (PND) 0 and 21 pups were analyzed for the toxic effects of PFOS. The results showed that maternal exposure to 2.0mg/kgd PFOS caused severe histopathological changes along with marked oxidative injuries and cell… CONTINUE READING
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