Prenatal Opiate Withdrawal Activates the Chick Embryo Hypothalamic-Pituitary-Adrenal Axis and Dilates Vitelline Blood Vessels via Serotonin2 Receptors

@article{Schrott2002PrenatalOW,
  title={Prenatal Opiate Withdrawal Activates the Chick Embryo Hypothalamic-Pituitary-Adrenal Axis and Dilates Vitelline Blood Vessels via Serotonin2 Receptors},
  author={L. Schrott and Mary Irene Baumgart and X. Zhang and S. Sparber},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2002},
  volume={303},
  pages={257 - 264}
}
  • L. Schrott, Mary Irene Baumgart, +1 author S. Sparber
  • Published 2002
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Opiate withdrawal during pregnancy may occur because of voluntary or forced detoxification, or from rapid cycling associated with exposure to short-acting “street” opiates. Thus, animal modeling of prenatal withdrawal and development of potential therapeutic interventions is important. Direct developmental effects of opiates and/or withdrawal can be studied using a chick model. In ovo administration of the long-acting opiateN-desmethyl-l-α-noracetylmethadol (NLAAM) induces opiate dependence in… CONTINUE READING
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