Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia

@inproceedings{Hui2018PrenatalIC,
  title={Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia},
  author={Chin Wai Hui and Abyga{\"e}l St-Pierre and Hassan El Hajj and Yvan Remy and S{\'e}bastien S. H{\'e}bert and Giamal N. Luheshi and Lalit Kumar Srivastava and Marie-{\`E}ve Tremblay},
  booktitle={Front. Mol. Neurosci.},
  year={2018}
}
Epidemiological studies revealed that environmental factors comprising prenatal infection are strongly linked to risk for later development of neuropsychiatric disorders such as schizophrenia. Considering strong sex differences in schizophrenia and its increased prevalence in males, we designed a methodological approach to investigate possible sex differences in pathophysiological mechanisms. Prenatal immune challenge was modeled by systemic administration of the viral mimic polyinosinic… CONTINUE READING
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