Prenatal Immune Challenge Disrupts Sensorimotor Gating in Adult Rats: Implications for the Etiopathogenesis of Schizophrenia

@article{Borrell2002PrenatalIC,
  title={Prenatal Immune Challenge Disrupts Sensorimotor Gating in Adult Rats: Implications for the Etiopathogenesis of Schizophrenia},
  author={Jos{\'e} Borrell and Jos{\'e} Miguel Vela and Angel Ar{\'e}valo-Mart{\'i}n and Eduardo Molina-Holgado and Carmen Guaza},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={26},
  pages={204-215}
}
Increasing evidence associates schizophrenia with prenatal exposure to infection. Impaired ability to “gate out” sensory and cognitive information is considered to be a central feature of schizophrenia and is manifested, among others, in disrupted prepulse inhibition (PPI) of the acoustic startle reflex. We analyzed the effect of a prenatal immune challenge— peripheral administration of bacterial endotoxin lipopolysaccharide (LPS) to pregnant female rats—upon PPI and immune function in adult… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
109 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 109 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…