Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer

@article{Palmer2006PrenatalDE,
  title={Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer},
  author={Julie R. Palmer and Lauren Anne Wise and Elizabeth E. Hatch and Rebecca Troisi and Linda T. Titus-Ernstoff and William C. Strohsnitter and Raymond H. Kaufman and Arthur L. Herbst and Kenneth L. Noller and Marianne Hyer and Robert N. Hoover},
  journal={Cancer Epidemiology Biomarkers \& Prevention},
  year={2006},
  volume={15},
  pages={1509 - 1514}
}
It has been hypothesized that breast cancer risk is influenced by prenatal hormone levels. Diethylstilbestrol (DES), a synthetic estrogen, was widely used by pregnant women in the 1950s and 1960s. Women who took the drug have an increased risk of breast cancer, but whether risk is also increased in the daughters who were exposed in utero is less clear. We assessed the relation of prenatal DES exposure to risk of breast cancer in a cohort of DES-exposed and unexposed women followed since the… 

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References

SHOWING 1-10 OF 40 REFERENCES

Risk of breast cancer in women exposed to diethylstilbestrol in utero: preliminary results (United States)

While not statistically significant, the overall 40% excess risk, arising exclusively from the subset of estrogen receptor-positive cases, raises a concern calling for continued investigation.

Breast cancer in mothers given diethylstilbestrol in pregnancy.

The incidence of breast cancer is moderately increased in women given DES, but the possibility that some unrecognized concomitant of DES exposure accounts for this increase cannot be excluded.

Evidence of prenatal influences on breast cancer risk

Perinatal Factors and Risk of Breast Cancer

The hypothesized association between intrauterine estrogen exposure and subsequent risk of breast cancer support the hypothesis that endogenous estrogen in utero is a possible risk factor for breast cancer.

Prenatal and Perinatal Risk Factors for Breast Cancer in Young Women

Some effect of early life exposures on breast cancer risk is indicated, although the role of estrogen exposure may be less central than previously suggested.

In-utero and early life exposures in relation to risk of breast cancer

Although the results from epidemiologic studies assessing prenatal exposures are consistent with the hypothesis concerning estrogen exposure, the specific biologic mechanisms remain largely unknown.

Birthweight as a risk factor for breast cancer

Birth characteristics and subsequent risk for breast cancer in very young women.

A J-shaped association between birth weight and breast cancer risk was found, and very high birth weight was associated with the greatest elevation in risk, supporting a role for early life factors in the development of breast cancer in very young women.

Intrauterine environment and breast cancer risk in women: a population-based study.

The findings suggest that estrogens and other hormonal factors, known to influence breast cancer risk in the adult, may also play a critical role during the intrauterine period.