Prenatal Diagnosis of β-Thalassemia Using Multiplex Allele-Specific Amplification (MASPCR) in Chinese Families.


Combining allele-specific amplification (ASPCR) with multiplex PCR, we developed a new approach-multiplex allele-specific amplification (MASPCR) to detect five common types of β-thalassemia mutations (CD 41-42(-4bp), CD 17 A→T, CD 71-72 (+ A), -28 A→ G and IVS-2-654 C→ T) which account for approximately 80% of all β-thalassemia alleles in Chinese… (More)
DOI: 10.1080/10245332.1996.11746312


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