Prenatal Dexamethasone Causes Oligonephronia, Sodium Retention, and Higher Blood Pressure in the Offspring

@article{Celsi1998PrenatalDC,
  title={Prenatal Dexamethasone Causes Oligonephronia, Sodium Retention, and Higher Blood Pressure in the Offspring},
  author={Gianni E Celsi and A. L. Kistner and Roman Aizman and Alexandra Ekl{\"o}f and Sandra Ceccatelli and Angelina De Santiago and Stefan H. Jacobson},
  journal={Pediatric Research},
  year={1998},
  volume={44},
  pages={317-322}
}
Recent reports have shown that low birth weight infants have a higher incidence of adult hypertension. These observations have stimulated a number of studies designed to evaluate the mechanisms of this phenomenon. In this study, fetal growth retardation was induced by treating pregnant rats with dexamethasone. After birth, pups whose mothers were treated with dexamethasone had a lower body and kidney weight and a lower number of glomeruli than control pups. Immunohistochemistry on treated… CONTINUE READING
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