Prenatal Adverse Effects of Various Drugs and Chemicals

  title={Prenatal Adverse Effects of Various Drugs and Chemicals},
  author={Monica Bologa-Campeanu and Gideon Koren and Michael Rieder and Michael A. Mcguigan},
  journal={Medical Toxicology and Adverse Drug Experience},
SummaryUsing the number of calls to the Canadian Motherisk Program as an indicator of the drugs and chemicals frequently of concern to mothers during pregnancy, the risks to the fetus of exposure to these compounds have been reviewed.The drugs which were of concern, and have been proven to be teratogenic, included alcohol, alkylating and antimetabolite agents, stilboestrol, disulfiram, heparin, lithium carbonate, phenytoin, tretinoin (retinoic acid), troxidone and valproic acid. For other… Expand
Dermatologic drugs in pregnancy.
Abstract Since the thalidomide disaster, there has been increasing concern about the association of therapeutic agents with teratogenicity. Although teratogenicity of thalidomide is now well defined,Expand
A multicenter, prospective study of fetal outcome following accidental carbon monoxide poisoning in pregnancy.
It is concluded that while severe CO poisoning poses serious short- and long-term fetal risk, mild accidental exposure is likely to result in normal fetal outcome and hyperbaric oxygen may decrease fetal hypoxia and improve outcome. Expand
Placental transfer of theophylline during in situ perfusion in the rabbit.
The rabbit placenta perfused in situ appears to be a useful preparation for measuring the transfer processes and the related and governing factors, of different compounds. Expand
WFSBP* and IAWMH** Guidelines for the treatment of alcohol use disorders in pregnant women
  • F. Thibaut, A. Chagraoui, +8 authors K. Yonkers
  • Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2019
There is no safe level of alcohol use during pregnancy and pharmacological treatment for maintenance of abstinence should not be used during pregnancy, due to the low level of evidence and/or to low benefit/risk ratio. Expand
Articles Received in 1988
  • 1989
148. BoUE, A. (1988) ‘The applications of molecular biology to the prenatal diagnosis of genetic diseases.’ (French.) Pkdiatrie, 43, 11-22. 149. CONNOR, J. M., FERGUSON-SMITH, M. A. (1988) ‘GeneticExpand
Reproductive Health Issues
Occupational health nurses and other health professionals are at the forefront of the issues of reproductive health in the workplace. Many complexities are involved, and the best informationExpand
A computer filing system for drug use in a pregnancy consultation service.
A computerized database for documenting drug use in pregnancy was set up on a personal computer and may be a potentially useful instrument not only for drug consultation services, but for individual physicians, too. Expand
Identification of At-risk Pregnant Population for Over-the-Counter Drug Usage in Low-Resource Settings
Nearly 1.5 billion people of an Asian country are living their lives without a country-specific over-the-counter (OTC) drug list. A study was planned to assess the understanding and practice of OTCExpand


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The synergistic relationship of tranquilizers-cigarettes with malformations supports existing pharmacologic research and suggests that epidemiologic study of the impact of simultaneous maternofetal exposure to environmental agents may further explain the etiology of some congenital malformation. Expand
Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development.
It is suggested that meprobamate, and possibly chlordiazepoxide, may be teratogenic when taken during the first six weeks of gestational diabetes, as well as other drugs, or no drug for minor psychoneurotic complaints (anxiety) during pregnancy. Expand
Are female sex hormones teratogenic?
It is concluded that the use of exogenous hormones during human pregnancy has not been proved to cause developmental abnormality in nongenital organs and tissues and the clinical, epidemiologic, and laboratory data permit the formulation of a rational approach to handling problems related to sex steroid usage and exposure in pregnant women. Expand
Aspirin in pregnancy: maternal and fetal effects.
Recent surveys of prenatal drug consumption indicate that aspirin is the most frequently consumed drug in pregnancy. Over the past several years, numerous reports have suggested a possibleExpand
Exogenous hormones and other drug exposures of children with congenital heart disease.
There is a small positive association between estrogen/progesterone exposure and cardiac malformation, but no association was evident between hormones and trunco-conal or any other class of defect among the cases, an observation which casts doubt on a causal relationship betweem hormones and cardiovascular malformations. Expand
It is concluded that although the risk of malformation is quite small it would be best to discontinue the use of hormonal agents for pregnancy testing. Expand
Teratogenic effects of benomyl in the Wistar rat and CD-1 mouse, with emphasis on the route of administration.
Benomyl did not affect postnatal growth, viability, or locomotor activity at subteratogenic doses, and the most sensitive indicator of perinatal exposure to benomyl via the po route of administration was a permanent reduction in testes and accessory sex gland weight noted in male offspring of dams. Expand
Cimetidine in pregnancy: apparent transient liver impairment in the newborn.
The finding of liver impairment in an infant born to a mother receiving cimetidine in the last trimester of her pregnancy is concerns, which indicates that this drug crosses the placental barrier and has thus the potential of producing a systemic effect in utero. Expand
Effects of lead on the female and reproduction: a review.
Experimental animal studies of leads effects are reviewed, evidence that women are more susceptible than men to the toxic effects of lead is evaluated, and evidence that the difference between the sexes may be due to hormonal effects of drug metabolism. Expand
Mercury toxicity in the pregnant woman, fetus, and newborn infant. A review.
The embryopathic and fetal toxic effects of mercury in general are identified while emphasizing the greater toxicity of methylmercury compounds. Expand